Last Updated on November 7, 2022 by
Losing weight can seem impossible. Trust me I know , I’ve been there. But with a proper diet and the right exercises, you can lose weight. Today I’m going to tell you how to lose weight naturally with this powerful Metformin dosages you should be taking when trying to lose weight.
You are probably wondering what is the right Metformin dosage for weight loss? Is there an easy answer? Unfortunately, there isn’t a precise answer to your question but it can be answered in a general way. There is not a specific dose of Metformin that will work for everyone. The dose needs to be individualized because some people will lose weight more quickly with lower doses and other people may need larger doses for significant weight loss. You can learn more about how Metformin Dosage For Weight Loss In Non Diabetics works by visiting my site at https://foodkeg.com/.
Metformin Dosage For Weight Loss In Non Diabetics

Metformin has a well-established safety profile and it has become clear that metformin has additional salutary effects, including anti-inflammatory, anti-aging, and anti-thrombotic properties. In this study, subjects will provide both venous blood samples and stool samples in addition to completing cognitive and physiologic testing at baseline, throughout a 90 day exposure to metformin, and 30 days following exposure to metformin in order to evaluate their immune, microbiome, cellular respiration, thrombotic, and inflammatory responses.
Condition or disease | Intervention/treatment | Phase |
---|---|---|
Inflammatory Response | Drug: MetFORMIN Hydrochloride ER | Phase 1Phase 2 |
Metformin is considered first-line therapy for patients with type two diabetes with hyperglycemia that cannot be controlled with lifestyle alone. Unlike other oral medications, metformin is favored for its insulin-sensitizing effects resulting in improved glycemic control, weight loss, and overall improvement of metabolic syndrome. Over the past fifteen years, metformin has received significant attention for its other potential therapeutic uses. Metformin has been found to decrease the rate of age-related illness progression improving longevity, especially in the setting of cancer. Recent clinical trials across multiple disease states have shown metformin to decrease all-cause mortality in diabetic and non-diabetic patients. Additionally, in both animal models and human trails, metformin has been shown to decrease the risk of arterial and venous thrombosis without affecting bleeding time through its interaction with platelet mitochondria. Although the mechanisms by which metformin effects longevity is an active area of both basic science and clinical research, it clearly has anti-inflammatory properties which are both independent and dependent of glycemic control. Recently, surgical outcomes have focused on optimizing older, deconditioned patients prior to the operation with varying protocols referred to as prehabilitation. These programs work to improve the body’s response to the surgical stress resulting in improved wound healing, decreased postoperative complications, and decreased hospital length of stay. The affect of metformin, like increasing physical activity, has widespread affects on physiology. The investigators, therefore, hypothesize that metformin administration to non-diabetic adults will improve clinical outcomes to physiologic stress by improving underlying immune and inflammatory responses, that can be deleterious.
Subjects will have venous samples collected to better understand the cellular response to inflammation, thrombosis, and cellular respiration at baseline, at 4 time points throughout the 90 day exposure to metformin, and 30 days following the completion of exposure to metformin. At the same time points, subjects will have stool samples collected in order to assess changes in their microbiome. Finally, subjects will undergo cognitive testing through the NIH toolbox as well as physiologic testing including (six-minute walk test, grip strength as measured by a dynamometer, and a short physical performance battery) at baseline, after 90 days of exposure, and again 30 days after the completion of exposure.
Study Design
Study Type : | Interventional (Clinical Trial) |
Actual Enrollment : | 32 participants |
Allocation: | Randomized |
Intervention Model: | Parallel Assignment |
Intervention Model Description: | Subjects will act as their own controls: data will be collect on each subject at baseline, throughout exposure and following, exposure to metformin. |
Masking: | None (Open Label) |
Primary Purpose: | Basic Science |
Official Title: | A Pilot Study: Metformin as an Inflammatory Modulating Therapy in Older Adults Without Diabetes |
Actual Study Start Date : | January 22, 2019 |
Actual Primary Completion Date : | March 31, 2020 |
Actual Study Completion Date : | March 31, 2020 |
Arm | Intervention/treatment |
---|---|
Experimental: 500mg exposureSubjects will be exposed to 500mg of daily MetFORMIN Hydrochloride ER for up to 90 days. | Drug: MetFORMIN Hydrochloride ERSubjects will be exposed to 500mg, 1000mg, or 1500mg of daily ER Metformin, by mouth, for up to 90 days. Subjects will have their venous blood sampled and baseline, throughout the trial, and following completion of their metformin exposure.Other Name: Metformin ER |
Experimental: 1000mg exposureSubjects will be exposed to 1000mg of daily MetFORMIN Hydrochloride ER for up to 90 days. | Drug: MetFORMIN Hydrochloride ERSubjects will be exposed to 500mg, 1000mg, or 1500mg of daily ER Metformin, by mouth, for up to 90 days. Subjects will have their venous blood sampled and baseline, throughout the trial, and following completion of their metformin exposure.Other Name: Metformin ER |
Experimental: 1500mg exposureSubjects will be exposed to 1500mg of daily MetFORMIN Hydrochloride ER for up to 90 days. | Drug: MetFORMIN Hydrochloride ERSubjects will be exposed to 500mg, 1000mg, or 1500mg of daily ER Metformin, by mouth, for up to 90 days. Subjects will have their venous blood sampled and baseline, throughout the trial, and following completion of their metformin exposure.Other Name: Metformin ER |
Can metformin help you lose weight?

Obesity is a serious global health concern, especially in the U.S. where 42.4% of Americans were classified as obese between 2017-2018.³
This disease results in a cascade of other health problems such as cardiovascular diseases (CVD) and type-2 diabetes. It can also lead to various types of cancer, which contribute to the deaths of many Americans every year.
Metformin is a first-line oral medication commonly prescribed to patients with type 2 diabetes or prediabetic patients with at least one cardiovascular disease risk factor, such as hypertension (high blood pressure).⁴ ⁵
Not only does metformin reduce blood glucose levels, but it can also induce moderate weight loss. This effect has been observed in both diabetic and non-diabetic individuals.⁶ ⁷
Although metformin has been shown to promote weight loss, just how it works remains unclear. Medical researchers have suggested that it may affect how the brain regulates appetite and food intake.⁶ Other studies have examined metformin’s effect on peripheral brain pathways, such as fat storage, hormone sensitivity, and body clock.
Metformin does not cause immediate weight loss. Instead, weight loss occurs gradually over a long period of time. A long-term diabetes prevention program (DPP) study observed weight-loss effects from metformin use over a period of up to two years, with participants losing an average of approximately six pounds after the first year and just under five pounds after two years.²
Over the next ten years, researchers followed up with patients who had responded well to metformin treatment, which showed they had maintained their weight loss.²
In a shorter study, metformin use was similarly found to have resulted in weight loss of up to 12 pounds in overweight or obese non-diabetic patients.⁷
These studies highlight how the effect metformin has on weight loss differs from person to person.²
Can metformin help you lose weight quickly?

Since metformin does not cause immediate weight loss, combining it with a healthy diet and regular exercise is an optimal approach to speed up the weight loss process.²
Another DPP study that followed up with patients taking metformin or implementing intensive lifestyle changes for almost three years after the study ended observed an average weight loss ranging between five to 12 pounds.⁸
A longer-term study showed that a significant proportion of patients taking metformin or those undergoing intensive lifestyle changes achieved weight loss of more than 5% over a 15-year period.⁹
Therefore, combining both metformin use and a healthy lifestyle may promote quicker and more significant weight loss.
Is metformin safe?
Clinical studies have not shown any major safety concerns associated with metformin use. In fact, there is limited evidence indicating starting treatment at a low dose of 500mg/day and increasing it slowly over time may mitigate any gastrointestinal side effects associated with metformin treatment.¹⁰ If the dose is tolerable, it can be slowly increased up to 2000mg/day.¹⁰
Recent research has also demonstrated that a low dose of metformin (1000-1500mg/day) can promote weight loss in non-diabetic individuals.¹¹ If you experience any side effects, you should consult your healthcare professional to discuss whether metformin is right for you.
What are the risks with metformin?
Despite metformin being a relatively safe drug, there are a few potential risks to note before starting treatment.
Blood glucose
Metformin acts by lowering blood glucose levels, so if your blood glucose levels are typically low (hypoglycemia), you should avoid taking this medication.
Co-administration of metformin with other diabetic therapies may also result in adverse drug interactions.²
Make sure to discuss with your healthcare professional whether you should take metformin. If you are taking it, check-in regularly with your doctor to monitor your blood glucose levels in order to adjust your dose to minimize any complications.
Renal impairment and lactic acidosis
Metformin may not be appropriate for you if you have a history of renal impairment.¹² This may result in lactic acidosis, the overproduction of lactic acid, which is a relatively rare side effect of metformin treatment. It is unclear whether metformin causes lactic acidosis or whether other predisposing factors cause it.¹³
If you have a history of renal complications, talk to your doctor to discuss whether metformin is an appropriate drug for you.
Gastrointestinal issues
Gastrointestinal problems (diarrhea, vomiting, nausea, and/or abdominal cramps) are a common side effect of taking many types of medication, including metformin. While the prevalence and severity tend to be relatively minor, you should consult your doctor if you are experiencing any issues.
The lowdown
Metformin is a common form of treatment for diabetic patients, but studies have shown that it also assists with weight loss. Generally, metformin is considered safe and well-tolerated with few side effects.¹⁴ However, the weight loss effects of metformin vary from person to person.
Metformin is not currently recommended as a therapy on its own for overweight or obese patients who do not also present with metabolic complications, such as diabetes or cardiovascular disease.
To find out whether metformin is a safe and appropriate treatment to help you lose weight, you should talk to your doctor or healthcare professional.